s. Marked increases were observed in the glycolytic capacity and glycolytic rate by circMAT2B‐overexpressing in hypoxic Huh7 and SMMC7721 cells, whereas both were reduced by circMAT2B knockdown in hypoxic HepG2 and Focus cells (Fig. 3D,E and Supporting Fig. S5C,D). Moreover, the mitochondrial function of oxidative phosphorylation was also influenced by circMAT2B levels, as reflected by the alteration in oxygen consumption and respiratory capacity. CircMAT2B overexpression under hypoxia led to an overtly decreased basal OCR and significantly lower maximum OCR compared with controls. Instead, under hypoxia, circMAT2B knockdown resulted in elevated OCR at both basal and maximal levels (Figs 3F,G and Supporting Fig. S5E,F).
To avoid trans‐splicing or genomic rearrangements, including head‐to‐tail splicing,
Analysis of SUVmax in the circMAT2B Low and circMAT2B High groups (n = 49; P < 0.001).
glycolysis‐related organic acids, G‐6‐P and L‐lactate,
four organic acids, glucose‐6‐phosphate (G‐6‐P), L‐lactate, L‐malate and α‐ketoglutarate
circMAT2B up‐regulated expression levels of the microRNA (miR)‐338‐3p target gene PKM2, which encodes a key enzyme in the process of glycolysis, through “sponging” miR‐338‐3p; thus, glycolysis and HCC progression are promoted through this mechanism. Conclusion: CircMAT2B promoted HCC progression by enhanced glycolysis by activating the circMAT2B/miR‐338‐3p/PKM2 axis under hypoxia, which may provide a therapeutic target for HCC.
circular RNA MAT2B (circMAT2B)
However, the mechanism underlying this switch remains to be elucidated.
相互作用前的判断比相互作用后的亲社会判断更负面。
面部照片是研究人际交往的有效代表
参与行为
如微笑,表现感兴趣,精力充沛,放松和健谈,这些都与更积极的人的判断有关。
通过编码交互中的行为,可以解释变更评级中的一些变化。它主要是参与行为,如微笑,表现感兴趣,精力充沛,放松和健谈,这些都与更积极的人的判断有关。
通过编码交互中的行为,可以解释变更评级中的一些变化。它主要是参与行为,如微笑,表现感兴趣,精力充沛,放松和健谈,这些都与更积极的人的判断有关。
更友好,但是被更强烈地评价为这样
他们的伴侣互动(T2)之后获得的社会命名判断与与威廉的T(T)之间的差异比较的编码行为之间的相关性。
参与行为增加了对宜人性,友善性,开放性,外向性的评价,能量学,大胆,寻求刺激和可喜性(但也有Disinhibition)和神经质和平均的评分略有下降
更为亲社会的判断有关
参与行为
这些参与行为,如健谈,能量,微笑,笑,玩耍,质疑和流畅